Duromine in metabolic syndrome

Metabolic syndrome is characterized by combination of risk factors of cardiovascular diseases and type 2 diabetes (including abdominal obesity, dyslipidemia, glucose intolerance and hypertension).

When obesity is accompanied by two or more disorders, the risk of cardiovascular diseases and diabetes increases significantly.

The primary goal of anti-obesity therapy is 10% of weight loss. Weight loss can be achieved by changing the lifestyle, namely by the help of a low-calorie diet and increased physical activity. If a lifestyle change is not enough for achieving a weight loss goal, doctors prescribe Duromine weight loss drug in addition to non-drug anti-obesity therapy.

Before starting a drug therapy with Duromine, people must realize that obesity is a chronic disease, so it requires a lifelong treatment. Fat was accumulated in the body for years, and to change that situation, overweight people should change their eating behavior for the rest of their life, but not just for the duration of weight loss therapy.

In order to maintain the result, achieved during anti-obesity therapy by means of Duromine, after the withdrawal of this weight loss drug, people should stick to a balanced diet and lead an active lifestyle (workouts, sports). A significant improvement of a patient’s clinical status with metabolic syndrome occurs when he gets a 5-10% of weight loss, regarding the initial body mass.

Along with weight loss in a person with metabolic syndrome, Duromine drug:

  • normalizes the night breathing
  • improves lipid profile
  • increases the cells sensitivity to insulin
  • provides normal blood pressure
  • reduces the risk of cardiovascular complications
In the lack of sufficient effect of anti-obesity therapy with Duromine and high risk of diabetes mellitus or atherosclerosis, drugs improving the cell sensitivity to insulin are prescribed (e.g. Metformin, insulin or Glimepiride).

Weight loss by means of Duromine intensifies therapeutic effect of Metformin, Glimepiride and insulin. Therefore, when a person takes anti-obesity drug Duromine, antidiabetic drugs are prescribed in low dosage.

If patients have critical levels of metabolic indices, to improve the lipid profile in addition to Duromine pills, doctors may prescribe:

  • Statins – HMG-CoA reductase inhibitors (Lovastatin, Pravastatin, Simvastatin, Atorvastatin)
  • Ezetimibe
  • Fibrates – fibric acid derivatives (Clofibrate, Gemfibrozil, Bezafibrate, Fenofibrate, Etofibrate)
  • Bile acid sequestrants – anion-exchange resins (Cholestyramine, Colestipol, Colesevelam)
  • Nicotinic acid
  • Omega-3-fatty acids (Omacor)
Hypolipidemic drugs are prescribed in a low dosage if they are included into the drug therapy with Duromine. The fact is that reduced amount of fat tissue improves the lipid profile. Therefore, hypolipidemic drugs may cause side effects: hypertriglyceridemia or kidney failure.

Metabolic syndrome improvement is achieved when one of its components is improved. For instance, Duromine causes weight loss, resulting in normal blood pressure and restored metabolic processes.

At the same time, Duromine weight loss drug increases tissue sensitivity to insulin, thereby improving compensation of carbohydrate metabolism. This will decrease the blood pressure, improving the lipid profile levels.